Hormones and Aging Hope Springs Eternal

Serum levels of total and bioavailable testosterone gradually decrease with age in men and are associated with changes in cognition. Cher-rier and coinvestigators (2001) examined the relationship between exogenous testosterone administration and cognitive abilities in a population of healthy older men. The investigators raised the circulating total testosterone in the treatment group an average of 130% from baseline at week 3 and 116% at week 6. Because of aromatization of testosterone, estradiol increased an average of 77% at week 3 and 73% at week 6 in the treatment group. Significant improvements in cognition were observed for spatial memory (recall of a walking route), spatial ability (block construction), and verbal memory (recall of a short story) in older men treated with testosterone compared with their baseline evaluation and the performance of the placebo group. Although no one has investigated if hormonal treatment with testosterone can restore the age-related decrease of creativity, it can increase the sex drive, which is not a bad side effect.

0 0

Post a comment