Transport Pathways Through The Stratum Corneum

As mentioned previously and shown in Figure 3, there are three pathways postulated for the diffusion of solutes through the SC: transcellular, intercellular (paracellular), and transappendageal. The following sections describe the nature of the transcellular and intercellular pathways as they relate to skin transport and examine the experimental and theoretical evidence for their existence. Transappendageal transport is examined as a separate section toward the end of this chapter. The transport of solutes through the nail plate is also considered later.

A. Transcellular Pathway

It was originally believed that transcellular diffusion mechanisms dominated over the intercellular and transappendageal routes during the passage of solutes through the SC (21). However, transport by the transcellular route would involve the repeated partitioning of the molecule between lipophilic and hydrophilic compartments, including the almost impenetrable corneocyte intracellular matrix of keratin and ker-atohyaline. Scheuplein further suggested that polar and nonpolar solutes permeate

Figure 4 Concepts addressed in this chapter.
Table 2 Early Reviews on Percutaneous Absorption






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  • pippin rumble
    What are the possible transport pathways through the stratum corneum?
    14 days ago

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