In 1940, Schwartz et al. (10) introduced an in vivo method to evaluate the efficacy of a vanishing cream against poison ivy extract utilizing visual erythema on human skin. The test cream was an effective prophylaxis against poison ivy dermatitis as compared to unprotected skin.
Sadler et al. (11) performed qualitative tests to evaluate the efficacy of barrier creams. One method used the fluorescence of a dyestuff and eosin as a measure of penetration; another measured the rates of penetration of water through barrier creams. These methods are rapid and simple, but provide only qualitative estimates. They introduced an apparatus for measuring the permeability of films of barrier creams.
Wahlberg (12,13) employed an isotope technique disappearance measurement for documenting the inhibiting effect of barrier creams on chromate (51Cr) percutaneous absorption in guinea pigs (Table 1 and Fig. 1) (13). In this series 2,4 Indulona® (which contains Na2HEDTA, Ca^EDTA and acidum ascorbicum as active ingredients) and 6, 10 Ivosin® (which contains the hydrochloride of a copolymerizate of p-divinyl benzol and p-m-dimethylaminomethyl-
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Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.