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styrol) absorption decreased as a result of pretreatment. In some cases, the disappearance technique was not sufficiently sensitive to permit quantitative determination. The disappearance measurements distinguished between different barrier creams, volumes per unit area, and intervals between application of cream and chromate (13).

Langford (14) introduced in vitro studies to determine the efficacy of the formulated FC resin complex to prevent solvent penetration through treated filter paper, solvent repellency on treated pigskin, and penetration of radio-tagged sodium lauryl sulfate through treated hairless mouse skin. The penetration rate of

Figure 2 Penetration rate of radio-tagged sodium lauryl sulfate/ETOH through hairless mouse skin. (Modified from Ref. 14.)

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