In the Draize human sensitization test (34), an occlusive patch containing the test material is applied to the upper arm or upper back of 200 volunteers for 48 h. The test site is evaluated at patch removal for erythema and edema. This process is repeated until a total of 9 to 10 patches have been applied. Ten to 14 days after application of the last induction patches, subjects are challenged via a patch applied to a new site for 48 h. Sites are visually evaluated at removal of the patch and the response at challenge is compared to the response to patches applied early in induction.
The RIPT procedure was modified to provide continuous patch exposure to the test material during a 3-week induction period (35,36). Patches are applied to |
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Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.