Over the past 15 years, much has changed with regard to the use and our under standing of both amphetamines and cocaine. Most notably, cocaine depend ence now appears to be differentially affecting poor, minority individuals who live in the inner city. This same population is overrepresented in the AIDS population. This confluence is not surprising, because both sex risk (including sex workers) and needle risk are associated with chronic use of cocaine. It therefore appears that these two epidemics are interconnected in a way that deserves close attention.
At the same time, there may be reason for cautious optimism with regard to the long-term effects of prenatal exposure to cocaine. Some of the early claims of devastating physical consequences to "crack babies" have proven to be exaggerated; experts in the perinatal addiction field now consider that many factors (e.g., poverty, poor maternal nutrition/health, smoking, and exposure to violence) combine to influence development. Molecular mechanisms of developmental neuroadaptation are at the same time beginning to be studied. In the future, we hope to understand better the physiological basis for the observed clinical events.
In the basic sciences area, we have come to understand more about the interactions of various neurotransmitters, drug reinforcement, and the reward pathway. Receptors are being subtyped and cloned. Signal transduction pathways, with their longer range on protein synthesis and genetic regulation, are being explored. We are beginning to make inroads in our understanding of sen-sitization and tolerance. Although pharmacological treatments for cocaine addiction have not yet proven successful in clinical trials, there are many exciting new avenues of pursuit. These prospects for pharmacological intervention are based on the remarkable advances in neuroscience being made in this decade.
Researchers also have been hard at work testing psychotherapeutic solutions to this complex problem. Cocaine dependence should not be viewed in isolation from other psychiatric conditions and life problems. Rather, we must consider how best to address the problem in the presence of other psychoactive substance use and non-substance-use Axis I and Axis II disorders. Depending on the larger clinical picture, successful treatment may require multiple or highly select therapies that are matched to the patient's pathology and adaptive strengths and resources. It is clear that a "one size fits all" approach to treatment of cocaine dependence is inappropriate; instead, an array of assessment tools is necessary to determine patient needs, along with a menu of cost-effective and readily available therapeutic strategies. Although American Society of Addiction Medicine (Hoffman, Halikas, Mee-Lee, & Weedman, 1991) criteria facilitate patient placement in an appropriate treatment setting based on addiction severity, they provide little guidance in terms of specific interventions to be delivered within those settings. Clinical research aimed at developing therapies for specific subtypes of cocaine addicts in a variety of settings is the most promising approach we now have.
Special thanks to Kenneth S. Kendler, MD, Rachel Brown Banks Distinguished Professor of Psychiatry and Professor of Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, for contributing to the genetic factors section of this chapter on genetic factors.
Abraham, H. D., & Fava, M. (1999). Order of onset of substance abuse and depression in a sample of depressed outpatients. Compr Psychiatry, 40, 44-50.
Allred, R. J., & Ewer, S. (1981). Fatal pulmonary edema following intravenous "free base" cocaine use. Ann Emerg Med, 10, 441-442.
American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed., text rev.). Washington, DC: Author.
Andrews, P. (1997). Cocaethylene toxicity. J Addict Dis, 16(3), 75-84.
Aroesty, D. J., Stanley, R. B., Jr., & Crockett, D. M. (1986). Pneumomediastinum and cervical emphysema from inhalation of "free based" cocaine: Report of three cases. Otolaryngol Head Neck Surg, 94, 372-374.
Aronson, T., & Craig, T. (1986). Cocaine precipitation of panic disorder. Am J Psychiatry, 143, 643-645.
Avila, A. H., Morgan, C. A., & Bayer, B. M. (2003). Stress-induced suppression of the immune system after withdrawal from chronic cocaine. J Pharmacol Exp Ther, 305, 290-297.
Azuma, S. D., &Chasnoff, I.J. (1993). Outcome of children prenatally exposed to cocaine and other drugs: A path analysis of three-year data. Pediatrics, 92, 396-402.
Bandstra, E. S., Morrow, C. E., Vogel, A. L., Fifer, R. C., Ofir, A. Y., Dausa, A. T., et al. (2002). Longitudinal influence of prenatal cocaine exposure on child language functioning. Neurotoxicol Teratol, 24, 297-308.
Barber, J., Frank, A., Weiss, R., & Blane, J. (1996). Prevalence and correlates of personality disorder diagnoses among cocaine dependent outpatients. J Pers Disord, 10, 297-311.
Barnett, G., Hawks, R., & Resnick, R. (1981). Cocaine pharmacokinetics in humans. J Ethnopharmacol, 3, 353-366.
Bartels, S., Teague, G., Drake, R., Clark R., Bush, P., & Noordsy, D. (1993). Service utilization and costs associated with substance abuse among rural schizophrenic patients. J Nerv Ment Dis, 181, 227-276.
Beckwith, L., Rodning, C., Norris, D., Phillipsen, L., Khandabi, P., & Howard, J. (1994). Spontaneous play in two-year-olds born to substance-abusing mothers. Infant Ment Health J, 15, 189-201.
Bien, T., Miker, W., & Tonigan, S. (1993). Brief interventions for alcohol problems: A review. Addiction, 8, 305-325.
Bierut, L. J., Dinwiddie, S. H., Begleiter, H., Crowe, R. R., Hesselbrock, V., Nurnberger, J. I., Jr., et al. (1998). Familial transmission of substance dependence: Alcohol, marijuana, cocaine, and habitual smoking: A report from the Collaborative Study on the Genetics of Alcoholism. Arch Gen Psychiatry, 55, 982-988.
Brady, K. T., Sonne, S., Randall, C. L., Adinoff, B., & Malcolm, R. (1995). Features of cocaine dependence with concurrent alcohol abuse. Drug Alcohol Depend, 39(1), 69-71.
Brown, J., & Miller, W. (1993). Impact of motivational interviewing on participation and outcome in residential alcoholism treatment. Psychol Addict Behav, 7, 211— 218.
Brown, R. A., Monti, P. M., Myers, M. G., Martin, R. A., Rivinus, T., Dubreuil, M. E., & Rohsenow, D. J. (1998). Depression among cocaine abusers in treatment: Relation to cocaine and alcohol use and treatment outcome. Am J Psychiatry, 155,
Budney, A. J., Higgins, S. T., Hughes, J. R., & Bickel, W. K. (1993). Nicotine and caffeine use in cocaine-dependent individuals. J Subst Abuse, 5, 117—130.
Bunt, G., Galanter, M., Lifshutz, H., & Castaneda, R. (1990). Cocaine/"crack" dependence among psychiatric inpatients. Am J Psychiatry, 147, 1542—1546.
Bystritsky, A., Ackerman, D., & Pasnau, R. (1991). Low dose desipramine treatment of cocaine-related panic attacks. J Nerv Ment Dis, 179, 755—758.
Carroll, K. (1996). Relapse prevention as a psychosocial treatment: A review of controlled clinical trials. Exp Clin Psychopharmacol, 4, 46—54.
Carroll, K., & Rounsaville, B. (1993). History and significance of childhood attention deficit disorder in treatment-seeking cocaine abusers. Compr Psychiatry, 34, 75—82.
Carroll, K., Rounsaville, B., Gordon, L., Nich, C., Jatlow, P., Bisighini, R., & Gawin, F. (1994). Psychotherapy and pharmacotherapy for ambulatory cocaine abusers. Arch Gen Psychiatry, 51, 177—187.
Carroll, K. M. (2000). Implications of recent research for program quality in cocaine dependence treatment. Subst Use Misuse, 35, 2011—2030.
Chasnoff, I. J., & Schnoll, S. H. (1987). Consequences of cocaine and other drug use in pregnancy. In A. Washton & M. S. Gold (Eds.), Cocaine: A clinician's handbook (pp. 241—251). New York: Guilford Press.
Church, M. W., & Subramanian, M. G. (1997). Cocaine's lethality increases during late gestation in the rat: A study of "critical periods" of exposure. Am J Obstet Gynecol, 176(4), 901—906.
Church, M. W., Kaufman, R. A., Keenan, J. A., Martier, S. S., Savoy-Moore, R. T., Ostrea, E. M., et al. (1991). Effects of prenatal cocaine exposure. In R. R. Watson (Ed.), Biochemistry and physiology of substance abuse (Vol. III, pp. 179—204). Boca Raton, FL: CRC Press.
Clark, T. A. (1996). Prevalence of drugs and alcohol in autopsied homicide cases in St. John Parish, Louisiana. J La State Med Soc, 148, 257—259.
Coffin, P. O., Galea, S., Ahern, J., Leon, A. C., Vlahov, D., & Tardiff, K. (2003). Opiates, cocaine and alcohol combinations in accidental drug overdose deaths in New York City, 1990—98. Addiction, 98, 739—747.
Cook, C. E. (1991). Pyrolytic characteristics, pharmacokinetics, and bioavailability of smoked heroin, cocaine, phencyclidine, and methamphetyamine. In M. A. Miller & N. J. Kozel (Eds.), Methamphetamine abuse: Epidemiologic issues and implications (NIDA Research Monograph No. 115, DHHS Publication No. ADM91-1836, pp. 6—23). Washington, DC: U.S. Government Printing Office.
Cooper, C. B., Bai, T. R., Heyderman, C., & Lorrin, B. (1983). Cellulose granulomas in the lungs of a cocaine sniffer. Br Med J, 286, 2121—2022.
Cottler, L. B., Compton, W. M., III, Mager, D., Spitznagel, E. L., & Janca, A. (1992). Posttraumatic stress disorder among substance users from the general population. Am J Psychiatry, 149, 664-670.
Cregler, L. L., & Mark, H. (1986). Special report: Medical complications of cocaine abuse. N Engl J Med, 315, 1495-1500.
Crits-Christoph, P., Siqueland, L., Blaine, J., Frank, A., Luborsky, L., Onken, L. S., et al. (1999). Psychosocial treatments for cocaine dependence: National Institute on Drug Abuse Collaborative Cocaine Treatment Study. Arch Gen Psychiatry, 56, 493-502.
DePetrillo, P. (1985). Getting to the base of cocaine. Emerg Med, 8, 8.
Estroff, T. W., Gold, M. S. (1986). Medical and psychiatric complications of cocaine abuse with possible points of pharmacological treatment. In B. Stimmel (Ed.), Controversies in alcoholism and substance abuse (pp. 61-75). New York: Haworth Press.
Farre, M., de la Torre, R., Llorente, M., Lamas, X., Ugena, B., Segura, J., et al. (1993). Alcohol and cocaine interactions in humans. J Pharmacol Exp Ther, 266, 13641373.
Frishman, W. H., Del Vecchio, A., Sanal, S., & Ismail, A. (2003). Cardiovascular manifestations of substance abuse: Part 1. Cocaine. Heart Dis, 5, 187-201.
Gawin, F. H., & Ellinwood, E. H., Jr. (1988). Cocaine and other stimulants: Actions, abuse, and treatment. N Engl J Med, 318, 1173-1182.
Gawin, F. H., Riordan, C., & Kleber, H. (1985). Methylphenidate treatment of cocaine abusers without attention-deficit disorder: A negative report. Am J Drug Alcohol Abuse, 11, 193-197.
Gay, G. R. (1982). Clinical management of acute and chronic cocaine poisoning. Ann Emerg Med, 11, 562-572.
General Accounting Office. (1990). Methadone maintenance: Some treatment programs are not effective, greater federal oversight needed. Washington, DC: Author.
Goeders, N. E. (2002). Stress and cocaine addiction. J Pharmacol Exp Ther, 301 (3), 785789.
Gold, M. S., Miller, N. S., & Jonas, J. M. (1992). Cocaine (and crack) neurobiology. In J. H. Lowinson, P. Ruiz, & R. B. Millman (Eds.), Substance abuse: A comprehensive textbook (2nd ed., pp. 222-235). Baltimore: Williams & Wilkins.
Goldfrank, L. R., & Hoffman, R. S. (1993). The cardiovascular effects of cocaine— update 1992. In H. Sorer (Ed.), Acute cocaine intoxication: Current methods of treatment (NIDA Research Monograph No. 123, NIH Publication No. 93-3498, pp. 70-109). Washington, DC: U.S. Government Printing Office.
Goldstein, R. Z., & Volkow, N. D. (2002). Drug addiction and its underlying neurobio-logical basis: Neuroimaging evidence for the involvement of the frontal cortex. Am J Psychiatry, 159, 1642-1652.
Griffin, M. L., Weiss, R. D., Mirin, S. M., & Lange, U. (1989). A comparison of male and female cocaine abusers. Arch Gen Psychiatry, 46, 122-126.
Haller, D., Knisely, J., Dawson, K., & Schnoll, S. (1993). Perinatal substance abusers: Psychological and social characteristics. J Nerv Ment Dis, 181, 509-513.
Henningfield, J. E., Clayton, R., & Pollin, W. (1990). Involvement of tobacco in alcoholism and illicit drug use. Br J Addict, 85, 279-291.
Higgins, S., Budney, A., Bickel, W., & Badger, G. (1994). Participation of significant others in outpatient behavioral treatment predicts greater cocaine abstinence. Am J Drug Alcohol Abuse, 20, 47-56.
Higgins, S., Budney, A., Bickel, W., Badger, G., Foerg, F., & Ogden, D. (1995). Outpatient behavioral treatment for cocaine dependence: One-year outcome. Exp Clin Psychopharmacol, 3, 205-212.
Higgins, S., Budney, A., Bickel, W., & Foerg, F. (1994). Incentives improve outcome in outpatient behavioral treatment for cocaine dependence. Arch Gen Psychiatry, 51, 568-576.
Higgins, S. T., Wong, C. J., Badger, G. J., Ogden, D. E., & Dantona, R. L. (2000). Contingent reinforcement increases cocaine abstinence during outpatient treatment and 1 year of follow-up. J Consult Clin Psychol, 68, 64-72.
Hoffman, N. G., Halikas, J. A., Mee-Lee, D., & Weedman, R. D. (1991). Patient placement criteria for the treatment of psychoactive substance use disorders. Washington, DC: American Society of Addiction Medicine.
Horner, B., Scheibe, K., & Stine, S. (1996). Cocaine abuse and attention-deficit hyperactivity disorder: Implications of adult symptomatology. Psychol Addict Behav, 10, 55-60.
Itkonen, J., Schnoll, S., & Glassroth, J. (1984). Pulmonary dysfunction in free base cocaine users. Arch Intern Med, 144, 2195-2197.
Jatlow, P., Hearn, W. L., Elsworth, J. D., Roth, R. H., Bradberry, C. W., & Taylor, J. R. (1991). Cocaethylene inhibits uptake of dopamine and can reach high plasma concentrations following combined cocaine and ethanol use. NIDA Res Monogr,
Javaid, J. I., Fischman, M. W., Schuster, C. R., Dekirmenjian, H., & Davis, J. M. (1978). Cocaine plasma concentration: Relation to physiological and subjective effects in humans. Science, 202, 227-228.
Johanson, C. E., & Schuster, C. R. (1995). Cocaine. In F. L. Bloom & D. J. Kupfer (Eds.), Psychopharmacology: The fourth generation of progress (pp. 1685-1697). New York: Raven Press.
Johnston, L. D., O'Malley, P. M., & Bachman, J. G. (2003). Monitoring the Future national survey results on drug use, 1975—2002. Vol. I: Secondary school students (NIH Publication No. 03-5375). Bethesda, MD: National Institute on Drug Abuse.
Jones, R. T. (1984). The pharmacology of cocaine. In J. G. Grabowski (Ed.), Cocaine: Pharmacology, effects and treatment of abuse (DHHS Publication No. ADM AD4-1325, pp. 34-53). Washington, DC: U.S. Government Printing Office.
Karam, E. G., Yabroudi, P. F., & Melhem, N. M. (2002). Comorbidity of substance abuse and other psychiatric disorders in acute general psychiatric admissions: A study from Lebanon. Compr Psychiatry, 43, 463-468.
Karkowski, L. M., Prescott, C. A., & Kendler, K. S. (2000). Multivariate assessment of factors influencing illicit substance use in twins from female-female pairs. Am J Med Genet, 96, 665-670.
Kelly, R. F., Sompalli, V., Sattar, P., & Khankari, K. (2003). Increased TIMI frame counts in cocaine users: A case for increased microvascular resistance in the absence of epicardial coronary disease or spasm. Clin Cardiol, 26, 319-322.
Kendler, K. S., Jacobson, K. C., Prescott, C. A., & Neale, M. C. (2003). Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins. Am J Psychiatry, 160, 687-695.
Khantzian, E. J., Gawin, F., Kleber, H. D., & Riordan, C. E. (1984). Methylphenidate treatment of cocaine dependence: A preliminary report. J Subst Abuse Treat, 1, 107-112.
Kirby, K. C., Marlowe, D. B., Festinger, D. S., Lamb, R. J., & Platt, J. J. (1998). Schedule of voucher delivery influences initiation of cocaine abstinence. J Consult Clin Psychol, 66, 761-767.
Kleinman, P., Miller, A., Millman, R., Woody, G., Todd, T., Kemp, J., & Lipton, D. (1990). Psychopathology among cocaine abusers entering treatment. J Nerv Ment Dis, 178, 442-447.
Koob, G. F. (1992). Neurobiological mechanisms in cocaine and opiate dependence. Res Publications Assoc Res Nerv Ment Dis, 70, 79-92.
Koob, G. F. (1997, April). Neurochemical explanations for addiction. Hosp Pract Special Rep, pp. 12-15.
Kosten, T. R. (1988). Cocaine treatment: Pharmacotherapies. Paper presented at the Clinical Applications of Cocaine Research: From Bench to Bedside meeting of the National Institute on Drug Abuse, Rockville, MD.
Kosten, T. R., Rounsaville, B. J., & Kleber, H. D. (1987). A 2.5 year follow-up of cocaine use among treated opioid addicts: Have our treatments helped? Arch Gen
Psychiatry, 44, 281-284.
Kranzler, H., Satel, S., & Apter, A. (1994). Personality disorders and associated features in cocaine-dependent inpatients. Compr Psychiatry, 35, 335-340.
Lambert, N. M., & Hartsough, C. S. (1998). Prospective study of tobacco smoking and substance dependencies among samples of ADHD and non-ADHD participants. J Learn Disabil, 31, 533-544.
Laposata, E. A., & Mayo, G. L. (1993). A review of pulmonary pathology and mechanisms associated with inhalation of freebase cocaine ("crack"). Am J Forensic Med Pathol, 14, 1-9.
Levin, F. R., Evans, S. M., & Kleber, H. D. (1998). Prevalence of adult attention-deficit hyperactivity disorder among cocaine abusers seeking treatment. Drug Alcohol Depend, 52, 15-25.
Lima, M. S., Soares, B. G., Reisser, A. A., & Farrell, M. (2002). Pharmacological treatment of cocaine dependence: A systematic review. Addiction, 97, 931-949.
Lombard, J., Levin, I. H., & Weiner, W. J. (1989). [Letter]. N Engl J Med, 320, 869.
Lukas, S. E. (1997). Proceedings of the national consensus meeting on the use, abuse, and sequelae of abuse of methamphetamine with implications for prevention, treatment and research (DHHS Publication No. SMA 96-8013, pp. 1-37). Washington, DC: U.S. Government Printing Office.
Lysaker, P., Bell, M., Beam-Goulet, J., & Milstein, R. (1994). Relationship of positive and negative symptoms to cocaine abuse in schizophrenia. J Nerv Ment Dis, 182, 109-122.
Marlatt, G. A., & Gordon, J. R. (1985). Relapse prevention: Maintenance strategies in the treatment of addictive behaviors. New York: Guilford Press.
Marlowe, D., Husband, S., Lamb, R., & Kirby, K. (1995). Psychiatric co-morbidity in cocaine dependence: Diverging trends, Axis II spectrum, and gender differentials. Am J Addict , 4, 70-81.
Martino, S., McCance-Katz, E., Workman, J., & Boozang, J. (1995). The development of a dual diagnosis partial hospital program. Continuum, 2, 145-165.
McCance-Katz, E. F., Price, L. H., McDougle, C. J., Kosten, T. R., Black, J. E., &Jatlow, P. I. (1993). Concurrent cocaine-ethanol ingestion in humans: Pharmacology, physiology, behavior, and the role of cocaethylene. Psychopharmacology, 111, 39-46.
McCarron, M. M., & Wood, J. D. (1983). The cocaine "body packer" syndrome: Diagnosis and treatment. JAMA, 250, 1417-1420.
McGonigal, M. D., Cole, J., Schwab, C. W., Kauder, D. R., Rotondo, M. F., & Angood, P. B. (1993). Urban firearm deaths: A five-year perspective. J Trauma, 35, 532536.
Miller, W., & Rollnick, S. (1991). Motivational interviewing: Preparing people to change addictive behavior. New York: Guilford Press.
Miner, L. L., & Marley, R. J. (1995). Chromosomal mapping of the psychomotor stimulant effects of cocaine in BXD recombinant inbred mice. Psychopharmacology, 122,
Mirin, S. M., Weiss, R. D., Griffin, M. L., & Michael, J. L. (1991). Psychopathology in drug abusers and their families. Compr Psychiatry, 32, 36-51.
Moore, T., Sorg, J., Miller, L., Key, T., & Resnik, R. (1986). Hemodynamic effects of intravenous cocaine on the pregnant ewe and fetus. Am J Obstet Gynecol, 155, 838-888.
Moos, R. H., Mertens, J. R., & Brennan, P. L. (1994). Rates and predictors of four-year readmission among late, middle-aged, and old substance abuse patients. J Stud Alcohol, 55, 561-570.
Moos, R. H., & Moos, B. S. (1995). Stay in residential facilities and mental health care as predictors of readmission for with patients with substance use disorders. Psychiatr Serv, 46, 66-72.
Muniz, A. E., & Evans, T. (2001). Acute gastrointestinal manifestations associated with use of crack. Am J Emerg Med, 19, 61-63.
Najavits, L. M., Gastfriend, D. R., Barber, J. P., Reif, S., Muenz, L. R., Blaine, J., et al. (1998). Cocaine dependence with and without PTSD among subjects in the National Institute on Drug Abuse Collaborative Cocaine Treatment Study. Am J Psychiatry, 155, 214-219.
New York State Division of Substance Abuse Services. (1990). NYS Office of Alcohol and Substance Abuse Services, program statistics [Data file]. Albany, NY: Author.
Nordahl, T. E., Salo, R., & Leamon, M. (2003). Neuropsychological effects of chronic methamphetamine use on neurotransmitters and cognition: A review. J Neuro-psychiatry Clin Neurosci, 15, 317-325.
Nurnberg, H. G., Rifkin, A., & Doddi, S. (1993). A systematic assessment of the comorbidity of DSM-III-R personality disorders in alcoholic outpatients. Compr Psyschiatry, 34, 447-454.
O'Brien, C., Childress, A., Arndt, I., & McLellan, T. (1988). Pharmacologic and behavioral treatments of cocaine dependence: Controlled studies. J Clin Psychiatry, 49(Suppl), 17-22.
O'Brien, C., Childress, A., McLellan, T., & Ehrman, R. (1990). Integrating systematic cue exposure with standard treatment in recovering drug dependent patients. Addict Behav, 15, 355-365.
Office of the Inspector General, Office of Evaluation and Inspections, and Department of Health and Human Services. (1990). Crack babies. Washington, DC: U.S. Government Printing Office.
O'Leary, M. E. (2002). Inhibition of HERG potassium channels by cocaethylene: A metabolite of cocaine and ethanol. Cardiovasc Res, 53, 59-67.
Patkar, A. A., Lundy, A., Leone, F. T., Weinstein, S. P., Gottheil, E., & Steinberg, M. (2002). Tobacco and alcohol use and medical symptoms among cocaine dependent patients. Subst Abuse, 23, 105-114.
Pristach, C. A., & Smith, C. M. (1990). Medication compliance and substance abuse among schizophrenic patients. Hosp Commun Psychiatry, 41, 1345-1348.
Prochaska, J., DiClemente, C., &Norcross, J. (1992). In search of how people change: Applications to addictive behavior. Am Psychol, 47, 1102-1114.
Rawson, R. A., Huber, A., Brethen, P., Obert, J., Gulati, V., Shoptaw, S., & Ling, W. (2002). Status of methamphetamine users 2-5 years after outpatient treatment. J Addict Dis, 21, 107-119.
Regier, D. A., Farmer, M. E., Rae, D. S., Locke, B. Z., Keith, S. J., Judd, L. L., & Goodwin, F. K. (1990). Comorbidity of mental disorders with alcohol and other drug abuse: Results from the Epidemiologic Catchment Area (ECA) study. JAMA, 264, 2511-2518.
Rosenthal, R., Hellerstein, D., Miner, C., & Christian, R. (1994). Positive and negative syndrome typology in schizophrenic patients with psychoactive substance use disorders. Compr Psychiatry, 35, 91-98.
Roth, D., Alarcon, F. J., Fernandez, J. A., Preston, R. A., & Bourgoignie, J. J. (1988). Acute rhabdomyolysis associated with cocaine intoxication. N Engl J Med, 319, 673-677.
Rounsaville, B. J., Anton, S. F., Carroll, K., Budde, D., Prusoff, B. A., & Gawin, F. (1991). Psychiatric diagnoses of treatment-seeking cocaine abusers. Arch Gen Psychiatry, 48, 43-51.
Schaper, A., Hofmann, R., Ebbecke, M., Desel, H., & Langer, C. (2003). Cocaine-body-packing: Infrequent indication for laparotomy. Der Chir, 74, 626-631.
Schindler, C. (1996). Cocaine and cardiovascular toxicity. Addiction Biology, 1, 31-47.
Schrank, K. S. (1993). Cocaine-related emergency department presentations. In H. Sorer (Ed.), Acute cocaine intoxication: Current methods of treatment (NIDA Research Monograph No. 123, NIH Publication No. 93-3498, pp. 110-128). Washington, DC: U.S. Government Printing Office.
Schuster, C. L., Yu, G., & Bates, A. (1977). Sensitization to cocaine stimulation in mice. Psychopharmacology, 52, 185-190.
Schwartz, M. S., Swanson, J. W., & Hannon, M. J. (2003). Detection of illicit substance use among persons with schizophrenia by radioimmunoassay of hair. Psychiatr Serv,
Seibyl, J., Satel, S., Anthoy, D., & Southwick, S. (1993). Effects of cocaine on hospital course in schizophrenia. J Nerv Ment Dis, 181, 31-37.
Seiden, L. S. (1991). Neurotoxicity of methamphetamine: Mechanisms of action and issues related to aging. In M. A. Miller & N. J. Kozel (Eds.), Methamphetamine abuse: Epidemiologic issues and implications (NIDA Research Monograph No. 115,
DHHS Publication No. ADM 91-1836, pp. 24-32). Washington, DC: U.S. Government Printing Office.
Seiden, L. S., & Sabol, K. E. (1996). Methamphetamine and methylenedioxymeth-amphetamine neurotoxicity: Possible mechanisms of cell destruction. In M. D. Majewska (Ed.), Neurotoxicity and neuropathology associated with cocaine abuse (NIDA Research Monograph No. 163, NIH Publication No. 96-4019, pp. 251276). Washington, DC: U.S. Government Printing Office.
Serper, M., Alpert, M., Richardson, N., & Dickson, S. (1995). Clinical effects of recent cocaine use on patients with acute schizophrenia. Am J Psychiatry, 152, 14641469.
Shaffer, H. J., & Eber, G. B. (2002). Temporal progression of cocaine dependence symptoms in the US National Comorbidity Survey. Addiction, 97, 543.
Shoptaw, S., Rawson, R. A., McCann, M. J., & Obert, J. L. (1994). The Matrix model of outpatient stimulant abuse treatment: Evidence of efficacy. J Addict Dis, 13,
Silverman, K., Higgins, S., Brooner, R., Montoya, I., Cone, E., Schuster, C., & Preston, K. (1996). Sustained cocaine abstinence in methadone maintenance patients through voucher-based reinforcement therapy. Arch Gen Psychiatry, 53, 409-415.
Simon, S. L., Domier, C., Carnell, J., Brethen, P., Rawson, R., & Ling, W. (2000). Cognitive impairment in individuals currently using methamphetamine. Am J Addict, 9(3), 222-231.
Singer, L. T., Arendt, R., Minnes, S., Farkas, K., Salvator, A., Kirchner, H. L., & Kliegman, R. (2002). Cognitive and motor outcomes of cocaine-exposed infants. JAMA, 287, 1952-1960.
Smith, J. E., Koves, T. R., & Co, C. (2003). Brain neurotransmitter turnover rates during rat intravenous cocaine self-administration. Neuroscience, 117, 461-475.
Stone, M. H. (1992). Borderline personality disorder: Course of illness. In J. F. Clarkin, E. Marziali, & H. Munroe-Blum (Eds.), Borderline personality disorder: Clinical and empirical perspectives (pp. 67-86). New York: Guilford Press.
Stotts, A. L., Schmitz, J. M., Rhoades, H. M., & Grabowski, J. (2001). Motivational interviewing with cocaine-dependent patients: A pilot study. J Consult Clin Psychol, 69, 858-862.
Substance Abuse and Mental Health Services Administration. (2001a). Drug Abuse Warning Network (DAWN) [Data file]. Rockville, MD: Author.
Substance Abuse and Mental Health Services Administration. (2001b). National Household Survey [Data file]. Rockville, MD: Author.
Substance Abuse and Mental Health Services Administration, Office of Applied Studies. (2002). Treatment Episode Data Set (TEDS): 1992-2000 (National Admissions to Substance Abuse Treatment Services, DASIS Series: S-17, DHHS Publication No. [SMA] 02-3727). Rockville, MD: Author.
Tames, S. M., & Goldenring, J. M. (1986). Madarosis from cocaine use. N Engl J Med, 314, 1324.
Tardiff, K., Marzuk, P. M., Leon, A. C., Hirsch, C. S., Stajic, M., Portera, L., & Hartwell, N. (1994). Homicide in New York City: Cocaine use and firearms. JAMA, 272, 43-46.
Texter, E. C., Chou, C. C., Merrill, S. L., Laureton, H. C., & Frohlich, E. D. (1964).
Direct effects of vasoactive agents on segmental resistance of the mesenteric and portal circulation: Studies with L-epinephrine, levarterenol, angiotensin, vaso-pressin, acetylcholine, methacholine, histamine, and serotonin. J Lab Clin Med, 64, 624-633.
Tsuang, M. T., Lyons, M. J., Eisen, S. A., Goldberg, J., True, W., Meyer, J. M., & Eaves, L. J. (1996). Genetic influences on abuse of illicit drugs: A study of 3,297 twin pairs. Am J Med Genet, 67, 473-477.
U.S. Department of Justice, Office of Justice Programs, National Institute of Justice. (2001). 2000 arrestee drug abuse monitoring: Annual report [Data file]. Washington, DC: Author.
U.S. Department of Justice, Office of Justice Programs, National Institute of Justice. (2003). National drug threat assessment, 2003 [Data file]. Washington, DC: Author.
Vidaeff, A. C., & Mastrobattista, J. M. (2003). In utero cocaine exposure: A thorny mix of science and mythology. Am J Perinat, 20, 165-172.
Volpe, J. (1992). Effect of cocaine use on the fetus. N Engl J Med, 327, 399-407.
Washton, A. M., Stone, N. S., & Hendrickson, E. C. (1988). Cocaine abuse. In D. M. Donovan & G. A. Marlatt (Eds.), Assessment of addictive behaviors (pp. 364-389). New York: Guilford Press.
Weber, J. E., Hollander, J. E., Murphy, S. A., Braunwald, E., & Gibson, C. M. (2003). Quantitative comparison of coronary artery flow and myocardial perfusion in patients with acute myocardial infarction in the presence and absence of recent cocaine use. J Thromb Thrombolysis, 14, 239-245.
Weiss, R. D, Mirin, S. M., Griffin, M. L., Gunderson, J. G., & Hufford, C. (1993). Personality disorders in cocaine dependence. Compr Psychiatry, 34, 145-199.
Weiss, R. D., Pope, H., & Mirin, S. (1985). Treatment of chronic cocaine abuse and attention-deficit disorder, residual type, with magnesium pemoline. Drug Alcohol Depend, 15, 69-72.
Wetti, C. V., Weiss, S. D., Cleary, T. J., & Gyori, E. (1984). Fungal cerebritis from intravenous drug use. J Forensic Sci, 29, 260-268.
Yahne, C. E., Miller, W. R., Irvin-Vitela, L., &Tonigan, J. S. (2002). Magdalena Pilot Project: Motivational outreach to substance abusing women street sex workers. J Subst Abuse Treatment, 23, 49-53.
Ziedonis, D., & Fischer, W. (1996). Motivation-based assessment and treatment of substance abuse in patients with schizophrenia. Dir Psychiatry, 16, 1-7.
Ziedonis, D., Rayford, B., Bryant, B., Kendall, J., & Rounsaville, B. (1994). Psychiatric comorbidity in white and African-American cocaine addicts seeking substance abuse treatment. Hosp Community Psychiatry, 45, 43-49.
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