Mechanism of Action

Ketamine is chemically similar to PCP but has important differences (Jansen, 1990). Ketamine binds to the NMDA receptor complex on the same site as PCP, located inside the calcium channel. It works by inhibiting several of the excitatory amino acid neurotransmitters (Cotman & Monaghan, 1987; Hampton et al., 1982). Ketamine works globally, affecting numerous neurotransmitter systems, but its action, as an NMDA antagonist, is likely the cause of its schizotypal and dissociative symptoms. NMDA blockade causes an increase in dopamine release in the midbrain and prefrontal cortex as well

(Bubser Keseberg, Notz, & Griffiths, 1992), and this is likely the cause of its ability to reinforce and cause dependence. Furthermore, persisting memory deficits have been demonstrated (Curran & Monaghan, 2001).

Natural Depression Cures

Natural Depression Cures

Are You Depressed? Heard the horror stories about anti-depressants and how they can just make things worse? Are you sick of being over medicated, glazed over and too fat from taking too many happy pills? Do you hate the dry mouth, the mania and mood swings and sleep disturbances that can come with taking a prescribed mood elevator?

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