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We would like to thank all the members of our laboratory for helpful discussions and critical reading of this manuscript, and our collaborators worldwide for their trust and patience.

Needless to say, we are much indebted to the patients and their families. This work was supported by the Fondation BNP-Paribas, the Fondation Schlumberger, and EU grant number QLK2-CT-2002-00846. JLC is an International Scholar of the Howard Hughes Medical Institute.


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