Get Rid Of Tiredness and Sleep Less
After an incubation period of 12 to 72 hours, symptoms may start with nausea and vomiting, followed by tiredness, headache, muscular paralysis, double vision, and respiratory problems, often with fatal results. The duration of botulism is 1 to 10 days, mortality is relatively high (30 to 65 ). In most foods, botulinum spores are of no consequence unless they are able to germinate and produce the toxin. The exception is infant foods in which botulinum spores are potentially infective and may give rise to toxicogenesis in the infant intestine. A good example of this is infant botulism caused by contaminated honey.
Based on the activity of modafinil in the forced swim test in animals, considered as predictive of some antidepressant activity in humans, several preliminary clinical studies demonstrated that modafinil was able to enhance the effects of antidepressant drugs, especially in patients with residual tiredness or fatigue.89 It was recently confirmed that modafinil was potentially effective as adjunctive therapy in depressed patients, particularly in those with problematic fatigue and sleepiness.90'91 Adjunct therapy of modafinil at initiation of treatment with a selective serotonin reuptake inhibitor (SSRI) improved the degree and onset of therapeutic effects in patients with major depressive disorder and fatigue.92 These beneficial effects may result from an enhancement by modafinil of the increase of extracellular serotonin levels induced by antidepressant drugs, such as fluoxetine and imipramine, in awake rat93 and a differential enhancement of serotonin efflux in distinct brain...
Fainting, tiredness or other complications. Care must be taken regarding concurrent illnesses, such as circulatory problems in the legs or brain, since a low blood pressure can aggravate these conditions. The target value for blood pressure management therefore varies from patient to patient and should always be determined individually. The experts have set a value of 130 80 mmHg as a guideline.
The most common symptom of chronic kidney failure, and one of the earliest, is fatigue. This can take the form of a constant feeling of tiredness, lack of a sensation of well-being, lack of energy, tiredness at the end of the day, or fatiguability (that is, becoming tired quickly during even mild activity). These types of fatigue are to be distinguished from shortness of breath on exertion and also from muscle fatiguability, such as weakness of the legs on walking or climbing stairs. As you might expect, many people have difficulty distinguishing the subtle differences between these symptoms.
Fatigue is a poorly defined symptom that may involve physical, mental, emotional, and motivational components (Smets et al., 1993 Ream and Richardson, 1996 Sharpe and Wilks, 2002). It is typically defined as extreme and persistent tiredness, weakness, or exhaustion that may be mental, physical, or both (Dittner et al., 2004). Thus, fatigue can refer to a subjective sensation or to objectively impaired performance (Sharpe and Wilks, 2002). Furthermore, patients use various words to describe fatigue (Smets et al., 1993), each of which may point to a different underlying etiology. For example, fatigue described as anhedonia (loss of interest and enjoyment) suggests depression, whereas prominent sleepiness indicates potential sleep disruption, which may in turn be due or irritability) to feeling fatigued A9. Difficulty completing daily tasks attributed to feeling fatigued A10. Perceived problems with short-term memory A11. Postexertional malaise lasting several hours
EDS and cataplexy are considered to be the two primary symptoms of narcolepsy, with EDS often the most disabling symptom. The EDS most typically mimics the feeling that people experience when they are severely sleep deprived, but may also manifest itself as a chronic tiredness or fatigue. Narcoleptic subjects generally experience a permanent background of baseline sleepiness that easily leads to actual sleep episodes in monotonous sedentary situations. This feeling is most often relieved by short naps (15-30 min), but in most cases the refreshed sensation only lasts a short time after awaking. The refreshing value of short naps is of considerable diagnostic value.
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